Genetic insights into the relationship between immune cell traits and abnormal uterine bleeding: A Mendelian randomization study.

ABSTRACT: Abnormal uterine bleeding (AUB) is an inflammatory response involving immune cells, but the relationship between immune cell traits and AUB is highly complex and still largely unclear. This study utilized genetic data from a genome-wide association study of European participants. Mendelian randomization (MR) analysis methods, including inverse variance weighted (IVW) as the primary approach, weighted median, MR Egger regression, and Mendelian randomization pleiotropy residual sum and outlier, were employed for forward and reverse analyses. Sensitivity analyses validated the stability and reliability of the results. The IVW method indicated a potential causal relationship between CD45 on granulocyte (odds ratio [OR] = 0.916, 95% CI: 0.880-0.954, P = 1.974 × 10-5) with a decreased risk of me

SUBMITTER: Ou W 

PROVIDER: S-EPMC11856939 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature