Association between air pollution and osteoporosis: A Mendelian randomization study.

ABSTRACT: Osteoporosis (OP) is a significant disease in the aging society, which poses a threat to the physical well-being of older adults. Some studies suggest that air pollution may contribute to an increased incidence of OP; however, this causal relationship has not been firmly established. To address this gap, we conducted Mendelian randomization (MR) analysis to assess the potential causal association between air pollution (including nitrogen dioxide [N = 456,380], nitrogen oxides [N = 456,380], particulate matter [PM]2.5 [N = 423,796], and PM10 [N = 455,314]) and total-body bone mineral density (BMD) (N = 56,284). We utilized summary data from IEU Open GWAS on the database of genome-wide association studies (GWAS) and employed inverse variance weighting (IVW) as our primary analytical approach

SUBMITTER: Ju M 

PROVIDER: S-EPMC11856944 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature