Chronic pharyngitis and cervical spondylosis risk: A bidirectional Mendelian randomization study.

ABSTRACT: Cervical spondylosis (CS) is the most prevalent degenerative disease among the elderly. Chronic pharyngitis (CP) has been reported as a contributing factor to CP. However, the causal relationship between CP and CS has not yet been established. This study aims to investigate the potential link between CP and CS. A bidirectional Mendelian randomization (MR) analysis was performed using genome-wide association studies. Single nucleotide polymorphisms for each trait were identified as instrumental variables. Several sensitivity analyses, including inverse-variance weighted (IVW) method, weighted median method, MR-Egger regression, MR-PRESSO, and outlier test, were conducted to validate MR assumptions. The analysis showed that CP influences the risk of CS, as evidenced by the IVW method (odds r

SUBMITTER: Li Y 

PROVIDER: S-EPMC11856965 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature