Melatonin for preventing postoperative delirium in elderly patients: A multicenter randomized placebo-controlled pilot study.

ABSTRACT:

Background

Postoperative delirium (POD) in older adults is associated with high risk of morbidity and mortality. With limited treatment options, prevention is essential. Melatonin has been suggested to prevent delirium through regulating the sleep-wake cycle and serotonin metabolism, which has been shown to be disrupted in patients with POD. However, the evidence regarding the use of melatonin for POD prevention is limited and inconclusive.

Methods

Our multicenter, 2-arm, parallel-group, feasibility randomized controlled trial evaluated the effect of melatonin on POD incidence after noncardiac surgery in patients >65 years (n = 120). Patients were randomized to 3 mg oral melatonin or placebo once preoperatively and for 7 days postoperatively. Patients were assessed twice dai

SUBMITTER: Khaled M 

PROVIDER: S-EPMC11856979 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature