Causal association between gastroesophageal reflux disease and sepsis, and the mediating role of gut bacterial abundance, a Mendelian randomization study.

ABSTRACT: Gastroesophageal reflux disease (GERD), akin to sepsis, is mediated by inflammatory reactions and exhibits a strong correlation with intestinal dysbiosis. We sought to examine whether these associations reflect causality using the Mendelian randomization (MR) mediation analysis. Genetic data were obtained from genome-wide association studies. Two-sample MR were performed to evaluate the causal association, accompanied by sensitivity analyses. Reverse direction MR was undertaken to assess the potential for reverse causation. Then, mediation analysis was performed to evaluate the mediating effect of gut bacterial pathway abundance in this relationship. Genetic predisposition to GERD was significantly associated with sepsis [inverse variance weighting: odds ratio = 1.366, P = 2.13E-09, 95% co

SUBMITTER: Fu Z 

PROVIDER: S-EPMC11857025 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature