Discovery of MK8383s with Antifungal Activity from Mangrove Endophytic Fungi <i>Medicopsis</i> sp. SCSIO 40440 Against Fusarium Wilt of Banana.

ABSTRACT: Fusarium wilt of banana (FWB), caused by Fusarium oxysporum f. sp. cubense (Foc) tropical race 4 (TR4), poses a severe threat to the global banana industry. The screening of endophytic fungi from the mangrove plant led to the identification of Medicopsis sp. SCSIO 40440, which exhibited potent antifungal activity against Fusarium. The further fraction of the extract yielded ten compounds, including MK8383 (1) and nine new analogues, MK8383s B-J (2-10). The structures of 1-10 were elucidated using extensive spectroscopic data and single-crystal X-ray diffraction analysis. In vitro antifungal assays revealed that 1 showed strongly antifungal activities against Foc TR4, with an EC₅₀ of 0.28 μg/mL, surpassing nyst

SUBMITTER: Zhou T 

PROVIDER: S-EPMC11857101 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature