Electrospun Membranes Loaded with Melanin Derived from Pecan Nutshell (Carya illinoinensis) Residues for Skin-Care Applications.

ABSTRACT: This study investigates the incorporation of melanin extracted from pecan nutshell residues into a polyacrylonitrile (PAN) matrix during the electrospinning of microfiber membranes. Melanin concentrations of 0.5, 2.0, and 5.0% w/w were incorporated to enhance the physicochemical and biological properties of the fibers. The melanin-loaded PAN fibers exhibited significant antioxidant activity against DPPH and ABTS radicals, with scavenging rates ranging from 46.58% to 62.77% and 41.02% to 82.36%, respectively, while unmodified PAN fibers showed no activity. Furthermore, the melanin-loaded membranes demonstrated antimicrobial effects. The membranes also exhibited an important enzyme inhibition activity against collagenase (37%), hyaluronidase (22%), tyrosinase (36%), and elastas

SUBMITTER: Garcia-Garcia M 

PROVIDER: S-EPMC11857193 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature