Isolation, Structure Elucidation and Biological Evaluation of Lomaiviticins F-H, Dimeric Benzofluorene Glycosides from Marine-Derived <i>Micromonospora</i> sp. Bacterium.

ABSTRACT: The discovery of new natural products remains a cornerstone of therapeutic innovation, and effective analytical tools for rapid dereplication can significantly accelerate this process. Using Isotopic Fine Structure (IFS) mass spectrometry, we rapidly identified three new dimeric benzofluorene glycosides, lomaiviticins F-H (1-3), from a marine-derived Micromonospora sp. bacterium. These compounds were isolated and structurally elucidated through advanced spectroscopic techniques, including FT-ICR-MS and NMR. Lomaiviticins F-H exhibit unique structural features, notably the 4-O-methyl-l-angolosamine moieties, which differentiate them from previously known lomaiviticins A-E. The discovery of these compounds highlights distinct biosynthetic linkages within the lomai

SUBMITTER: Zhang F 

PROVIDER: S-EPMC11857394 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature