What Is the Impact of Obesity-Related Comorbidities on the Risk of Premature Aging in Patients with Severe Obesity?: A Cross-Sectional Study.

ABSTRACT: Background and Objectives: The relationships between aging, chronic diseases, and obesity remain complex and poorly understood. This study aimed to investigate the impact of comorbidities on premature aging in individuals with severe obesity. Materials and Methods: This cross-sectional study included 99 bariatric patients with severe obesity (SG) and 30 healthy volunteers (HC). SG was further divided into subgroups based on comorbidity status. Various markers of biological aging, including interleukin-6 (IL-6), C-reactive protein (CRP), telomere length (TL), attention speed, executive functions, and metabolic age, were evaluated. Results: Both subgroups of patients with obesity presented elevated levels of IL-6 and CRP, shorter TLs, lower outcomes in executive function

SUBMITTER: Dudek A 

PROVIDER: S-EPMC11857414 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature