Analysis of Biomarker Levels in Nasopharyngeal Swabs, Serum, and Saliva Across Different Health Conditions.

ABSTRACT:

Background

Coronavirus disease 2019 (COVID-19) is associated with a wide variety of clinical manifestations.

Aim

This study aims to evaluate the levels of angiotensin-converting enzyme 2 (ACE2), metalloprotease 17 (ADAM17), Interleukin-17A (IL-17A), transmembrane serine protease 2 (TMPRSS2), apelin (AP), and vitamin D (VD) biomarkers in nasopharyngeal swab (NPS), serum, and saliva, as well as the change in their values depending on the health status of individuals.

Material and methods

The analysis was performed by using enzyme-linked immunosorbent assay (ELISA) methods.

Results

Comparing the levels of the investigated markers in saliva, we found significantly elevated ACE2 values in vaccinated patients, followed by those with severe COVID-19, compared to healt

SUBMITTER: Pencheva M 

PROVIDER: S-EPMC11857456 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature