Statins Diversity Revealed by the Deep-Sea-Derived Fungus Penicillium viridicatum.

ABSTRACT: Seven new (1-7) and six known (8-13) statin derivatives were obtained from the deep-sea-derived fungus Penicillium viridicatum MCCC 3A00265. The structures assigned to the new compounds were based on a comprehensive analysis of the spectroscopic data, with absolute configurations established by Mosher analysis and biogenetic consideration. Most of the new compounds (1-5 and 7) share an octohydronaphthalene backbone, except that viridecalin F (6) possesses an uncommon naphthalene core. Viridecalins C (3) and F (6) and the two known compounds 9 and 11 exhibit considerable ability in reactivating mutant p53 protein at 10 μM, while viridecalin C showcases the most potent reactivation activity, indicating

SUBMITTER: Zhang M 

PROVIDER: S-EPMC11857571 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature