Inflammatory Markers as Predictors of Diabetic Nephropathy in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.

ABSTRACT: Background and Objectives: Diabetic nephropathy (DN) is a major complication of diabetes mellitus and a leading cause of end-stage renal disease. Inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and red cell distribution width (RDW) have been proposed as potential predictors of DN progression. This study systematically reviews and meta-analyzes the role of these markers in DN. Materials and Methods: A comprehensive literature search was conducted to identify studies evaluating NLR, PLR, SII, and RDW in type 2 diabetes patients with normoalbuminuria, microalbuminuria, and macroalbuminuria. Five databases were searched: PubMed, Scopus, Embase, Web of Science, and LILACS. The Newcastl

SUBMITTER: Leucuta DC 

PROVIDER: S-EPMC11857583 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature