Differences in Metabolite Profiles and Bioactivities of Intra-Strain Variants of Marine Fungus Penicillium antarcticum KMM 4668.

ABSTRACT: Background: During the cultivation of the marine fungus KMM 4668 on solid agar medium, the morphological instability of the strain was observed. As a result of the selection work, five intra-strain variants, named KMM 4711, KMM 4712, KMM 4713, KMM 4714, and KMM 4715, were obtained. Methods: The main objectives of this work were to compare the parent strain and its intra-strain variants using multi-locus phylogenetic analysis and to study the UPLC MS metabolite profiles and cytotoxic activities of their extracts. Results: A study of the original strain, KMM 4668, and its intra-strain variants using multi-locus phylogenetic analysis showed that they are sequence identical and belong to Penicillium antarcticum. UPLC MS metabolite profiling of fungal extracts reveal

SUBMITTER: Borkunov GV 

PROVIDER: S-EPMC11857625 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature