Identification of Plasma Metabolites Responding to Oxycodone Exposure in Rats.

ABSTRACT:

Background

Oxycodone has an elevated abuse liability profile compared to other prescription opioid medications. However, many human and rodent metabolomics studies have not been specifically focused on oxycodone.

Objectives

Investigating metabolomics changes associated with oxycodone exposure can provide insights into biochemical mechanisms of the addiction cycle and prognosis prediction.

Methods

Plasma samples from 16 rats at pre-exposure and intoxication time points were profiled on the Metabolon platform. A total of 941 metabolites were characterized. We employed a k-Nearest Neighbor imputation to impute metabolites with low levels of missingness and binarized metabolites with moderate levels of missingness, respectively.

Results

Of the 136 binarized metabol

SUBMITTER: Vu T 

PROVIDER: S-EPMC11857688 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature