An Evaluation of Neuron-Specific Enolase as a Biomarker of Neurological Impact in Pacemaker-Implanted Patients with Atrial High-Rate Episodes: An Observational Study from Turkey.

ABSTRACT: Background and Objectives: An atrial high-rate episode (AHRE) is defined according to the European Society of Cardiology (ESC) guidelines as a heart rate of ≥175 bpm lasting at least 5 min. This study aimed to evaluate whether neuron-specific enolase (NSE) levels, an indicator of neurological impact, could serve as a surrogate biomarker for silent neurological ischemia in patients with atrial high-rate episodes (AHREs). Materials and Methods: Patients with AHRE detected in a pacemaker analysis and a control group without any arrhythmias were included. Patients with AHRE were divided into subgroups according to AHRE duration-Group 1: AHRE < 5 min, Group 2: AHRE ≥ 5 min-<1 h, Group 3: AHRE ≥ 1 h-<24 h, Group 4: AHRE ≥ 24 h. Neuron-specific enolase (NSE) levels were measured usi

SUBMITTER: Cinar A 

PROVIDER: S-EPMC11857707 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature