Proteomic Diversity of the Sea Anemone <i>Actinia fragacea</i>: Comparative Analysis of Nematocyst Venom, Mucus, and Tissue-Specific Profiles.

ABSTRACT: Sea anemones (Actiniaria, Cnidaria) are promising targets for biomedical research, as they produce unique bioactive compounds, including toxins and antimicrobial peptides (AMPs). However, the diversity and mechanisms underlying their chemical defenses remain poorly understood. In this study, we investigate the proteomic profiles of the unexplored sea anemone Actinia fragacea by analyzing its venom nematocyst extract, tissues, and mucus secretion. A total of 4011 different proteins were identified, clustered into 3383 protein groups. Among the 83 putative toxins detected, actinoporins, neurotoxins, and phospholipase A2 were uncovered, as well as two novel zinc metalloproteinases with two specific domains (ShK) associated with potassium channel inhibition. Common Gene Ontology (GO) te

SUBMITTER: Barroso RA 

PROVIDER: S-EPMC11857728 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature