Nanoparticle-Based DNA Biosensor: Synthesis of Novel Manganese Nanoparticles Applied in the Development of a Sensitive Electrochemical Double-Stranded/Single-Stranded DNA Biosensor.

ABSTRACT: The development of electrochemical DNA biosensors occurred by applying different organically coated Mn-NPs such as MnCO₃@OAm, MnCO₃@TEG and MnO₂/Mn₂O₃@TEG, as well as naked MnCO₃ NPs (where OAm = oleylamine and TEG = tetraethylene glycol). The detection performances of PGEs were modified with different types of Mn-NPs, according to the guanine signal magnitudes obtained after double-stranded DNA (dsDNA) or single-stranded DNA (ssDNA) immobilization at these surfaces. DNA interaction studies were realized using UV-vis, circular dichroism (CD), electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV) techniques. In addition, a 3- to 5.4-fold increase in guanine response in the presence of dsDNA and

SUBMITTER: Ozkan-Ariksoysal D 

PROVIDER: S-EPMC11857743 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature