Potential Biomarkers of Fatal Hypothermia Revealed by UHPLC-MS Metabolomics in Mice.

ABSTRACT:

Background

The postmortem diagnosis of fatal hypothermia presents a considerable challenge in forensic medicine. Metabolomics, a powerful tool reflecting comprehensive changes in endogenous metabolites, offers significant potential for exploring disease mechanisms and identifying diagnostic markers.

Methods

In this study, we employed ultra-high-performance liquid chromatography-mass spectrometry (UHPLC-MS) to perform a non-targeted metabolomic analysis of liver, stomach, spleen, and musculus gastrocnemius tissues from mice subjected to fatal hypothermia.

Result

A substantial number of differential metabolites were identified in each tissue: 1601 in the liver, 420 in the stomach, 732 in the spleen, and 668 in the gastrocnemius muscle. The most significantly altered met

SUBMITTER: Cao XZ 

PROVIDER: S-EPMC11857787 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature