The Detection of Extensively Drug-Resistant Proteus mirabilis Strains Harboring Both VIM-4 and VIM-75 Metallo-β-Lactamases from Patients in Germany.

ABSTRACT: Proteus mirabilis is a well-known opportunistic pathogen predominantly associated with urinary tract infections. It exhibits natural resistance to multiple antibiotics, including last-resort options like colistin. The emergence and spread of multidrug-resistant P. mirabilis isolates, including those producing ESBLs, AmpC cephalosporinases, and carbapenemases, are now more frequently reported. The most common carbapenemase types found in P. mirabilis are KPC-2, IMP, VIM, NDM, and OXA-48. We sequenced the genomes of three carbapenem-resistant P. mirabilis isolates harboring both bla_VIM-4 and bla_VIM-75 from Germany using both short-read and long-read sequencing techniques. We found that the isolates were only distantly related ge

SUBMITTER: Fritzenwanker M 

PROVIDER: S-EPMC11857796 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature