Predictive Value of Direct Disk Diffusion Testing from Positive Blood Cultures for Detection of Antimicrobial Nonsusceptibility.

ABSTRACT: Antibiotic resistance poses a significant global threat, particularly in the context of bloodstream infections. Early antimicrobial susceptibility testing plays a crucial role in guiding clinicians to optimize treatment and enhance patient outcomes. Direct disk diffusion testing (dDDT), utilizing positive blood culture broth as an inoculum, provides results one day earlier than the standard method using bacterial colonies. This retrospective study evaluated the ability of dDDT to predict nonsusceptibility to commonly used antibiotics. From January 2021 to December 2023, a total of 1473 blood cultures positive for a single pathogen (Enterobacterales, Pseudomonas aeruginosa, Staphylococcus aureus, β-hemolytic streptococci, or Enterococcus spp.) were examined. The results

SUBMITTER: Wong TT 

PROVIDER: S-EPMC11857890 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature