¹¹C-Labeling of a Flavanone Extracted from a South American Native Species for Evaluation of Its Interaction with GSK-3β.

ABSTRACT: Natural products play a crucial role in drug discovery, primarily due to their structural complexity. The prenylated flavanone glabranin ((S)-5,7-dihydroxy-8-(3-methylbut-2-en-1-yl)-2-phenylchroman-4-one), isolated from the Dalea elegans plant species, has demonstrated neuroprotective effects, attributed to its inhibition of GSK-3β, as per our previous in silico studies. Given the enzyme's diverse functions and its potential as a target for neurodegenerative diseases, our group synthesized and evaluated an ¹¹C-labeled derivative of glabranin. We present its in vitro biological activity, including IC₅₀, neuronal uptake in Alzheimer's-affected brain regions, key physicochemical properties, and animal studies. This study confirms [¹¹C]FLA's interaction with GS

SUBMITTER: Zeni M 

PROVIDER: S-EPMC11857971 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature