Identification and Therapeutic Potential of Polymethoxylated Flavones in <i>Citri Reticulatae Pericarpium</i> for Alzheimer's Disease: Targeting Neuroinflammation.

ABSTRACT: Neuroinflammation is a significant driving force in the pathogenesis and progression of central nervous system (CNS) disorders. Polymethoxylated flavones (PMFs), the key lipid-soluble constituents in Citri Reticulatae Pericarpium (CRP), exhibit excellent blood-brain barrier permeability and anti-inflammatory properties, holding therapeutic potential for CNS disorders. However, the specific bioactive components and therapeutic effects of PMFs in treating CNS disorders are not well understood. This study employed a comprehensive sequential metabolism approach to elucidate the dynamic biotransformation of PMFs in vivo and identified seven brain-targeting components. Subsequently, network pharmacology and experimental validation were utilized to explore the potential mechanisms of PMFs.

SUBMITTER: Wang X 

PROVIDER: S-EPMC11857992 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature