Taxane-Producing Fungi Isolated from Taxus globosa Tree Bark.

ABSTRACT: The taxane molecules extracted from the bark of trees from the Taxus genus demonstrate anticancer activity and are the main components of the drug paclitaxel. Even though a great deal of research has been carried out to produce them synthetically, this manufacturing is still dependent on Taxus cell culture. Furthermore, these processes are not suitable for steady taxane production. Therefore, the search for alternative sources of taxane production has generated growing interest amongst the scientific community. The use of endophytic fungi for the obtention of taxane constitutes an attractive alternative. Here, we present an analysis of the taxane production of several microorganisms through LC-QTOF MS/MS. We isolated 21 endophytic fungus strains, identified through sequencing

SUBMITTER: Guevara-Sanchez JG 

PROVIDER: S-EPMC11858034 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature