Understanding Host-Pathogen Interactions in Congenital Chagas Disease Through Transcriptomic Approaches.

ABSTRACT: Chagas disease, caused by Trypanosoma cruzi, is a parasitic zoonosis with significant health impacts, particularly in Latin America. While traditionally associated with vector-borne transmission, increased migration has expanded its reach into urban and non-endemic regions. Congenital transmission has become a critical route of infection, involving intricate maternal-fetal immune interactions that challenge diagnosis and treatment. This review synthesizes findings from three RNA-seq studies that explore the molecular underpinnings of congenital Chagas disease, emphasizing differentially expressed genes (DEGs) implicated in host-pathogen interactions. The DAVID tool analysis highlighted the overexpression of genes associated with the innate immune response, including pro-inflammatory

SUBMITTER: Caceres TM 

PROVIDER: S-EPMC11858232 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature