Contrasting Effect of Curcumin on Hepatitis B Virus Replication According to the Hepatoma Cell Line.

ABSTRACT: In recent decades, considerable advances have been achieved in the treatment of chronic hepatitis B. However, the currently available drugs have shortcomings. In this context, several natural compounds have been proposed as potential agents to improve either the outcome of antiviral treatment or the progression of chronic infection, with curcumin being one of the most evaluated compounds due to its pleiotropic antiviral activity. The aim of this study was to characterize the effect and mechanism of curcumin on hepatitis B virus (HBV) replication in two different experimental models. Treatment of HepG22.15 and HBV-transfected Huh7 cells with curcumin revealed that the phytochemical differentially modulated HBV replication in both cell lines. In HepG22.15 cells, the addition of curcumin had

SUBMITTER: Elizalde MM 

PROVIDER: S-EPMC11858270 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature