Oxidative Balance Score Calculated Using Different Methods and Its Associations with Colorectal Cancer Risk.

ABSTRACT:

Background

The oxidative balance score (OBS) measures oxidative stress from diet and lifestyle, but research linking it to colorectal cancer (CRC) risk is scarce and varies in calculation methods.

Methods

We conducted a case-control study in Guangzhou, China, involving 2799 CRC cases and an equal number of sex- and age-matched controls. We adopted and compared four different methods for calculating the OBSs. The odds ratio (OR) and 95% confidence interval (95%CI) for the relationship between OBS and CRC risk were determined using an unconditional logistic regression model. Restricted cubic splines were used to explore potential non-linear relationships. Additionally, stratified analyses were performed by sex, and subgroup analyses were performed based on the tumor site.

R

SUBMITTER: Lin F 

PROVIDER: S-EPMC11858281 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature