Exploring E-Vape Aerosol Penetration into Paranasal Sinuses: Insights from Patient-Specific Models.

ABSTRACT: Background: Acute and chronic sinusitis significantly impact patients' quality of life. Effective drug delivery to paranasal sinuses is crucial for treating these conditions. However, medications from conventional devices like nasal drops, sprays, and nebulized mists often fail to penetrate the small ostia and reach the sinuses. This study aims to assess the effectiveness of e-vape-generated aerosols entering and filling paranasal sinus cavities, particularly the maxillary sinus. Methods: The aerosol droplets were generated using an electronic vaporizer (e-vape) and were composed solely of vegetable glycerin (VG) and propylene glycol (PG). Patient-specific, transparent nose-sinus models, including one with post-uncinectomy surgery, were used to evaluate the effectiveness of t

SUBMITTER: Seifelnasr A 

PROVIDER: S-EPMC11858401 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature