The Impact of Long-Term Parenteral Nutrition on Physical Development and Bone Mineralization in Children with Chronic Intestinal Failure.

ABSTRACT:

Background

This cross-sectional study aimed to assess growth, body weight, and bone mineralization and to identify predictors of metabolic bone disease (MBD) in children with chronic intestinal failure (CIF) on long-term parenteral nutrition (LPN).

Methods

Twenty-six children with CIF were evaluated on total parenteral nutrition (PN) for at least three years, and 60 healthy controls were assessed. Measurements included body weight, height, BMI, serum levels of 25-hydroxyvitamin D3 (25-OHD3), calcium (Ca), phosphorus (P), magnesium (Mg), and aluminum (Al), as well as urinary excretion of these elements. Dual-energy X-ray absorptiometry (DXA) and the mid-arm muscle area (MAMA) and mid-arm fat area (MAFA) of the CIF group were estimated.

Results

CIF children had signific

SUBMITTER: Romanowska H 

PROVIDER: S-EPMC11858412 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature