Cholesin mRNA Expression in Human Intestinal, Liver, and Adipose Tissues.

ABSTRACT:

Objective

Cholesin is a recently discovered gut-derived hormone secreted by enterocytes upon dietary cholesterol uptake via the transmembrane sterol transporter Niemann-Pick disease C1-like intracellular cholesterol transporter 1 (NPC1L1). In the liver, cholesin activates G protein-coupled receptor 146 (GPR146), causing reduced cholesterol synthesis. In this exploratory, hypothesis-generating study based on post hoc analysis, human data on the cholesin system are presented.

Methods

Mucosal biopsies were collected throughout the intestinal tract from 12 individuals with type 2 diabetes (T2D) and 12 healthy, matched controls. Upper small intestinal mucosal biopsies were collected from 20 individuals before and after Roux-en-Y gastric bypass (RYGB) surgery. Liver biopsies were

SUBMITTER: Gilliam-Vigh H 

PROVIDER: S-EPMC11858417 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature