Reactive Dicarbonyl Scavenging with 2-Hydroxybenzylamine Improves MASH.

ABSTRACT: Background: Products of lipid peroxidation include a number of reactive lipid aldehydes including reactive dicarbonyl electrophiles (DEs) and contribute to disease processes. DEs play a significant role in the development and progression of metabolic-associated steatotic liver disease (MASLD) by contributing to oxidative stress, inflammation, protein dysfunction, and mitochondrial impairment. Reducing DE stress may be a potential strategy for managing MASLD. We hypothesized that the DE scavenger 2-hydroxybenzylamine (2-HOBA) would reduce liver injury by reducing liver protein adduct formation by DE in mouse models of MASLD. Methods: Protein adducts were measured in human livers by immunohistochemistry and immunoblot. The effects of 2-HOBA were assessed in two different mouse

SUBMITTER: Cheung-Flynn J 

PROVIDER: S-EPMC11858443 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature