Dietary Fatty Acid Composition Alters Gut Microbiome in Mice with Obesity-Induced Peripheral Neuropathy.

ABSTRACT:

Background

Peripheral neuropathy (PN), a complication of diabetes and obesity, progresses through a complex pathophysiology. Lifestyle interventions to manage systemic metabolism are recommended to prevent or slow PN, given the multifactorial risks of diabetes and obesity. A high-fat diet rich in saturated fatty acids (SFAs) induces PN, which a diet rich in monounsaturated fatty acids (MUFAs) rescues, independent of weight loss, suggesting factors beyond systemic metabolism impact nerve health. Interest has grown in gut microbiome mechanisms in PN, which is characterized by a distinct microbiota signature that correlates with sciatic nerve lipidome.

Methods

Herein, we postulated that SFA- versus MUFA-rich diet would impact gut microbiome composition and correlate with PN dev

SUBMITTER: Noureldein MH 

PROVIDER: S-EPMC11858455 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature