Synthesis of Thiazolo[5,4-d]thiazoles in an Eco-Friendly L-Proline-Ethylene Glycol Mixture.

ABSTRACT: The hazardousness of solvents used in synthetic organic chemistry is well established. In this context, it is relevant to search for safer and greener alternatives. Within the last decades, deep eutectic solvents have been considered as possible and promising alternatives. Consequently, this study aims at using deep eutectic solvents to synthesize an emerging class of heteroaromatic compounds named thiazolo[5,4-d]thiazoles, for which interest is growing in the field of organics, electronics, and biology. To address this challenge, we developed a straightforward synthetic protocol consisting of condensing dithiooxamide and aromatic aldehyde in deep eutectic solvents to yield the desired thiazolo[5,4-d]thiazole without further purification. The first hit was obtained with the w

SUBMITTER: Nguyen TTT 

PROVIDER: S-EPMC11858519 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature