Preliminary Data on the Senolytic Effects of Agrimonia pilosa Ledeb. Extract Containing Agrimols for Immunosenescence in Middle-Aged Humans: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparison Study.

ABSTRACT:

Objectives

To assess the effects of agrimol-containing Agrimonia pilosa Ledeb. extract (APE) for senescent immune cell removal in middle-aged Japanese adults with immunosenescence.

Design and setting

A randomized, double-blind, placebo-controlled, parallel-group study was conducted in Japan between June 2023 and April 2024.

Participants

110 individuals aged 40-59, selected based on CD8+ T cells with highly-expressing-senescence-associated-β-galactosidase (SA-βGal).

Intervention

Participants were randomly assigned to receive 50 mg APE containing 0.2 mg of agrimols or a placebo for eight consecutive weeks.

Measurements

The primary endpoint was the change in the proportion of CD8+ T cells with high SA-βGal expression at 8 weeks of intake from the bas

SUBMITTER: Shimizu Y 

PROVIDER: S-EPMC11858573 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature