Development and Techno-Economic Evaluation of Crystallization Techniques for GABA Purification from Fermentation Broth.

ABSTRACT: γ-aminobutyric acid, a critical neurotransmitter, is experiencing an increasing demand in the medical and health fields. Conventional processes for γ-aminobutyric acid purification from fermentation broth encounter significant challenges, such as high ethanol usage, low yield, complex process flow, and environmental pollution. Therefore, a purification process based on crystallization techniques was developed to address the above issues. The process was implemented in two stages: desalination and γ-aminobutyric acid treatment. Na₂SO₄ was effectively removed through a cooling crystallization technique. γ-aminobutyric acid with a purity of 98.66% and a yield of 67.32% was further obtained through a designed "antisolvent-cooling" crystallization process in a 3.2 L system

SUBMITTER: Jing Y 

PROVIDER: S-EPMC11858641 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature