Genomic Characterization of Carbapenemase-Producing Klebsiella pneumoniae ST895 Isolates from Canine Origins Through Whole-Genome Sequencing Analysis.

ABSTRACT: The widespread application of carbapenems and other broad-spectrum antibiotics has significantly escalated the threat posed by highly drug-resistant Klebsiella pneumoniae to human public health. In this research, we isolated a carbapenem-resistant K. pneumoniae strain from the feces of pet dogs at a veterinary hospital in Changchun, Jilin Province, China. To gain insights into its genetic makeup and resistance mechanisms, we conducted comprehensive whole-genome sequencing and antimicrobial susceptibility testing on the isolated strain. Our findings revealed the presence of three distinct plasmids within the strain, classified as IncFIB&IncFII, IncR, and IncX3. Notably, the bla_NDM-5 gene, conferring resistance to carbapenems, was uniquely harbored on the IncX

SUBMITTER: Huang R 

PROVIDER: S-EPMC11858644 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature