Two-Week Low-Salt Diet Improves Acetylcholine-Induced Microvascular Dilation in Biologically Naive Psoriasis Patients.

ABSTRACT: Background/Objectives: Patients with psoriasis exhibit endothelial dysfunction (EDy), which increases their cardiovascular risk. Excessive salt intake impairs endothelium-dependent vascular reactivity. However, research on EDy in psoriasis has focused primarily on larger vessels, leaving skin microcirculation unexplored. This study aimed to investigate the effects of a low-salt diet (LS diet, ~3.75 g/day) on microvascular reactivity in patients with chronic plaque psoriasis. Methods: Laser Doppler flowmetry was used to assess skin microcirculation blood flow in response to vascular occlusion (postocclusive reactive hyperemia, PORH), acetylcholine (acetylcholine-induced dilation, AChID), sodium nitroprusside (SNP-induced dilation, SNPID), and local heating (local thermal hyper

SUBMITTER: Krajina I 

PROVIDER: S-EPMC11858809 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature