Inhibitory Effect of Nano-Formulated Extract of Passiflora incarnata on Dalton's Lymphoma Ascites-Bearing Swiss albino Mice.

ABSTRACT: Background/Objectives: This study explored the antitumor effect of Passiflora incarnata leaves' nanoformulation (N-EEP) in fibroblasts, A375 cell lines, and in vivo using Dalton's lymphoma ascites (DLA)-bearing mice. Methods: N-EEP treatment could significantly slow scratch closing in A375 cells compared to in the extract itself (EEP). Results: The hemolytic assay showed that N-EEP had less than 2% hemolysis, making the formulation highly biocompatible. In vivo N-EEP administration delayed the tumor growth rate, reduced weight gain, and increased the tumor-bearing mice's life span. Furthermore, the ascitic cells were aspirated from the tumor and investigated for various gene expressions. The tumor suppressor gene p53, which plays a significant role in the mitochondrial

SUBMITTER: Deepika B 

PROVIDER: S-EPMC11859039 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature