Targeting Zfp36 to combat cardiac hypertrophy: Insights into ferroptosis pathways.

ABSTRACT:

Background

Cardiac hypertrophy is a precursor to heart failure and represents a significant global cause of mortality, thereby necessitating timely and effective therapeutic interventions. Zinc finger protein 36 (Zfp36) is recognised as a critical regulator of ferroptosis; however, its role and underlying mechanisms in cardiac hypertrophy remain largely unexplored. This study aims to investigate the regulatory function of Zfp36 in ferroptosis within the context of cardiac hypertrophy.

Methods and results

Single-cell sequencing analysis demonstrated a reduction in Zfp36 expression associated with cardiac hypertrophy. Zfp36 was observed to mitigate ferroptosis and reduce hypertrophic phenotypes in cardiomyocytes subjected to Angiotensin II (Ang II) and in myocardial tissues in

SUBMITTER: Zhang M 

PROVIDER: S-EPMC11859123 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature