Fluorescent Probes to Image the K_Ca3.1 Channel in Tumor Cells.

ABSTRACT: Background/Objectives: The Ca²⁺-activated K⁺ channel K_Ca3.1 is not only involved in physiological processes such as immune reactions and control of vascular tone, but is highly expressed in various tumor entities. Thus, imaging of K_Ca3.1 channels comes into focus for the localization of high channel density, i.e., for tumor diagnosis. In particular, the physicochemical properties of the fluorescent probes should be improved compared to existing probes. Methods: The small molecule inhibitor of the K_Ca3.1 channel, senicapoc, was used as a warhead and was coupled with different fluorescent dyes. After synthesis of the novel probes, their physicochemical properties (lipophilicity, photophysical properties) and their ability t

SUBMITTER: Thale I 

PROVIDER: S-EPMC11859423 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature