Sustained Delivery of Liraglutide Using Multivesicular Liposome Based on Mixed Phospholipids.

ABSTRACT: Background: Although peptides are widely used in the clinical treatment of various diseases due to their strong biological activity, they usually require frequent injections owing to their poor in vivo half-life. Therefore, there is a strong clinical need for sustained peptide formulations. Methods: In this study, liraglutide (Lir) and biocompatible multivesicular liposomes (MVLs) were utilized as the model drug and sustained-release carriers, respectively. The drug release rate of Lir-MVLs was controlled by changing the ratio of SPC and DEPC with different phase transition temperatures (PTT, PTT_SPC = -20 °C, PTT_DEPC = 13 °C). Results: As the SPC ratio increased, Lir-MVLs had more flexible lipid membranes, poorer structural stabilization, and fewe

SUBMITTER: Zhang R 

PROVIDER: S-EPMC11859442 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature