Development and Blood-Brain Barrier Penetration of Nanovesicles Loaded with Cannabidiol.

ABSTRACT: Background: Cannabidiol (CBD) is a highly lipophilic compound with potential therapeutic applications in neurological disorders. However, its poor aqueous solubility and bioavailability, coupled with instability in physiological conditions, significantly limit its clinical use. Objectives: This study aimed to develop and characterize nanovesicles incorporating Tween 20 to enhance CBD encapsulation, stability, and the performance across the blood-brain barrier (BBB). Methods: Nanovesicles were prepared via thin-film hydration followed by sonication and optimized for size, polydispersity index, and zeta potential. Stability studies were conducted under physiological conditions and during storage at 4 °C. In vitro release studies employed the dialysis bag method, while pe

SUBMITTER: Grifoni L 

PROVIDER: S-EPMC11859449 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature