Methods to crosswalk between cognitive test scores using data from the Alzheimer's Disease Neuroimaging Cohort.

ABSTRACT:

Introduction

Studies use multiple different instruments to measure dementia-related outcomes, making head-to-head comparisons of interventions difficult.

Methods

To address this gap, we developed two methods to crosswalk estimated treatment effects on cognitive outcomes that are flexible, broadly applicable, and do not rely on strong distributional assumptions.

Results

We present two methods to crosswalk effect estimates using one measure to estimates using another measure, illustrated with global cognitive measures from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Specifically, we develop crosswalks for the following measures and associated change scores over time: the clinical dementia rating scale sum of box (CDR-SB), Montreal Cognitive Assessment (MoCA)

SUBMITTER: Ackley SF 

PROVIDER: S-EPMC11859661 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature