Genome-wide profiling of N6-methyladenosine-modified pseudogene-derived long noncoding RNAs reveals the tumour-promoting and innate immune-restraining function of RPS15AP12 in ovarian cancer.

ABSTRACT:

Background

Pseudogene-derived lncRNAs are widely dysregulated in cancer. Technological advancements have facilitated the functional characterization of increasing pseudogenes in cancer progression. However, the association between pseudogenes and RNA N6-methyladenosine (m⁶A) modification in cancer, as well as the underlying mechanisms, remains largely unexplored.

Methods

We analyzed the expression of 12 146 pseudogenes and comprehensively examined the m⁶A modification of RNAs derived from them and their paralogs. Through integrative analysis of multi-omics data, we explored the associations between pseudogene dysregulation and m⁶A, identifying critical pseudogenes involved in HGSOC progression. Tumour promotion role of RPS15AP12 and its cogna

SUBMITTER: Xu J 

PROVIDER: S-EPMC11859666 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature