Predictive Value of STC2 Gene Expression in Chemotherapy Response in Breast Cancer.

ABSTRACT: Background: Breast cancer is the most commonly diagnosed cancer among women, and resistance to chemotherapy presents a significant challenge in its treatment. Stanniocalcin-2 (STC2), a glycoprotein involved in calcium homeostasis and cellular stress responses, is frequently overexpressed in various human cancers. Despite its critical role in cellular adaptation to stress, the potential of STC2 as a biomarker for predicting chemotherapy response has not been evaluated. This study aimed to assess the potential of STC2 as a predictive biomarker of response to chemotherapy in breast cancer. Methods: We utilized publicly available databases to characterize STC2 expression in breast cancer patients and its role in predicting relapse-free survival (RFS). Moreove

SUBMITTER: Munoz JP 

PROVIDER: S-EPMC11859796 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature