IR813-Induced Photothermal Therapy: Leveraging Immunogenic Cell Death for Cancer Treatment.

ABSTRACT: Background: Photothermal therapy has the potential to enhance the precision and safety of oncological treatments. However, applicable photothermal agents associated with its photothermal activated immunogenic cell death remain exploiting. Methods: This study evaluates the effectiveness of IR813, a photothermal agent, combined with near-infrared (NIR) light for cancer treatment. In vitro, 4T1 cancer cells were treated with IR813 (5 μg/mL) and exposed to NIR irradiation (1 W/cm²) for 5 min. In vivo, after the tumor-bearing mice administered with IR813 (1 mg/kg) and exposed to NIR irradiation (1 W/cm²) for 10 min, the tumor volume, survival and immune activation were evaluated. Results: IR813 significantly increased the cytotoxicity of 4T1 cancer cel

SUBMITTER: Jiang G 

PROVIDER: S-EPMC11859857 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature