Revealing the antimicrobial potential of traditional Chinese medicine through text mining and molecular computation.

ABSTRACT: Traditional Chinese Medicine (TCM), with its extensive knowledge base documented in ancient texts, offers a unique resource for contemporary drug discovery, particularly in combatting microbial infections. The success of antimalarial drugs like artemisinin and artesunate, derived from the TCM herb Artemisia annua L., exemplifies the potential of TCM-derived small molecules. This rich repository of natural products and intricate molecular structures could reveal novel compounds with unexplored mechanisms of action. Our study employs a multifaceted approach that combines text mining, detailed textual analysis, and modern antibacterial molecular prediction methodologies to unlock the potential of ancient TCM remedies. We use external knowledge maps, which include databases of known bioactive

SUBMITTER: Chung MC 

PROVIDER: S-EPMC11859959 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature