Synthesis and Characterization of Memantine-Loaded Niosomes for Enhanced Alzheimer's Disease Targeting.

ABSTRACT: Background/Objectives: Over the past 25 years, numerous biological molecules, like recombinant lysosomal enzymes, neurotrophins, receptors, and therapeutic antibodies, have been tested in clinical trials for neurological diseases. However, achieving significant success in clinical applications has remained elusive. A primary challenge has been the inability of these molecules to traverse the blood-brain barrier (BBB). Recognizing this hurdle, our study aimed to utilize niosomes as delivery vehicles, leveraging the "molecular Trojan horse" technology, to enhance the transport of molecules across the BBB. Methods: Previously synthesized memantine derivatives (MP1-4) were encapsulated into niosomes for improved BBB permeability, hypothesizing that this approach could mini

SUBMITTER: Turkez H 

PROVIDER: S-EPMC11860023 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature