Toward the Optimal Choice of Gelled Vehicles for Oral Drug Administration in Dysphagic Patients.

ABSTRACT: Background/Objectives: Thickened waters are commonly used for dysphagic patients to ensure hydration, facilitate safer swallowing, and administer oral therapies, yet their impact on drug dissolution remains unclear. This study aims to investigate how thickening agents, viscosity, and solid oral dosage form (SODF) formulations influence drug release in gelled vehicles. Methods: Twelve commercially available thickened waters, including both ready-to-use products and powders for extemporaneous preparation, were used to disperse crushed sodium pravastatin tablets. The resulting preparations were evaluated for their rheological properties and dissolution performance. Results: Thickened water products vary in consistency, with starch-based thickeners providing more consisten

SUBMITTER: Logrippo S 

PROVIDER: S-EPMC11860041 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature