Serum alpha-1 acid glycoprotein and gallstone risk in US adult women: a cross-sectional analysis of the NHANES.

ABSTRACT:

Background

Gallstone disease, a common biliary disorder, is linked to inflammation and immune responses. However, the association between serum alpha-1 acid glycoprotein (AGP), a key inflammatory marker, and gallstone risk remains underexplored.

Methods

Data from the National Health and Nutrition Examination Survey (NHANES) 2017-2020 and 2021-2023 cycles were analyzed. Gallstone disease was determined by self-reported physician diagnosis. Serum AGP levels were measured using a high-sensitivity turbidimetric immunoassay. Weighted logistic regression, subgroup analyses, smoothed curve analysis, and multiple imputation were used to examine the relationship between AGP and gallstone risk.

Results

This cross-sectional analysis included 1,903 adult women in the U.S. aged 20

SUBMITTER: Li X 

PROVIDER: S-EPMC11860086 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature