Relationship of METS-IR with cardiometabolic multimorbidity in China: a nationwide longitudinal cohort study.

ABSTRACT:

Background

Cardiometabolic multimorbidity (CMM) has emerged as a global health challenge with a high mortality risk. This study aimed to explore the association between the metabolic score for insulin resistance (METS-IR) and the incidence of CMM.

Methods

This study included 6,977 individuals in the CHARLS database. We used multiple cox proportional hazards regression and restricted cubic splines (RCS) analysis to evaluate the association between METS-IR and CMM. Subgroup analyses and interaction tests were also performed.

Results

During a median 109 (108-109) months of follow-up, 745 (10.7%) participants were diagnosed with new-onset CMM. The incidences of CMM among participants in quartiles (Q) 1-4 of METS-IR were 4.99, 7.51, 10.67, and 19.54%, respectively. METS-IR

SUBMITTER: Zhou C 

PROVIDER: S-EPMC11860098 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature